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PhD in Physical Chemistry, 2018
Trinity College Dublin
Bachelor's Degree in Chemistry, 2014
Trinity College Dublin
Postgraduate Certificate in Statistics, 2017
School of Computer Science and Statistics, Trinity College Dublin
Diploma in Python Programming, 2020
CCT College Dublin
Nanodegree in Data Science with Python, 2021
Udacity (Remote Learning Course)
Laureate of AMI Emergence Entrepeneurship Programme, 2022
Deeptech Bretagne
Conjugation of biomolecules on the surface of nanoparticles (NPs) to achieve active targeting is widely investigated within the scientific community. However, while a basic framework of the physicochemical processes underpinning bionanoparticle recognition is now emerging, the precise evaluation of the interactions between engineered NPs and biological targets remains underdeveloped. Here, we show how the adaptation of a method currently used to evaluate molecular ligand–receptor interactions by quartz crystal microbalance (QCM) can be used to obtain concrete insights into interactions between different NP architectures and assemblies of receptors. Using a model bionanoparticle grafted with oriented apolipoprotein E (ApoE) fragments, we examine key aspects of bionanoparticle engineering for effective interactions with target receptors. We show that the QCM technique can be used to rapidly measure construct–receptor interactions across biologically relevant exchange times. We contrast random adsorption of the ligand at the surface of the NPs, resulting in no measurable interaction with target receptors, to grafted oriented constructs, which are strongly recognized even at lower graft densities. The effects of other basic parameters impacting the interaction such as ligand graft density, receptor immobilization density, and linker length were also efficiently evaluated with this technique. Dramatic changes in interaction outcomes with subtle alterations in these parameters highlight the general importance of measuring the interactions between engineered NPs and target receptors ex situ early on in the construct development process for the rational design of bionanoparticles.
Committed to Open Access Publishing
Trained in statistical analysis
“Environmental and depollution applications of electroactive bacteria: from denitrification to iron bioremediation” September 2024: Invited Webinar for the “French Group of Bioelectrochemistry”
“Tailored Carbon Nanomaterial Interfaces for Electrocatalysis, Electroanalysis and Microbial Fuel Cell Applications” European Materials Research Society (EMRS) Spring Meeting 2022
I was delighted to present our work at EMRS for the first time post-pandemic. The symposium was replete with very interesting presentations on carbon nanomaterials and our small section on biological applications generated a lot of discussion despite being the afternoon session towards the end of the programme. I came away feeling up to date on nanocarbons and energised to try all sorts of new experiments in the lab - exactly what you want from a world class international conference!
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